Sains Malaysiana 52(7)(2023): 2037-2053

http://doi.org/10.17576/jsm-2023-5207-12

 

The Ameliorative Effects of Selenium Nanoparticles (SeNPs) on Diabetic Rat Model: A Narrative Review

(Kesan Amelioratif Selenium Nanozarah (SeNPs) pada Model Tikus Diabetik: Suatu Ulasan Naratif)

 

ANAS AHZARUDDIN AHAMAD TARMIZI1, SITI HAJAR ADAM2*, NIK NASIHAH NIK RAMLI1, NUR AHFIZAH ABD HADI1, ABDUL MUTALIB MAISARAH1, SHIRLEY GEE HOON TANG3 & MOHD HELMY MOKHTAR4

 

1School of Graduate Studies (SGS), Management and Science University, University Drive, Off Persiaran Olahraga, 40100 Shah Alam, Selangor, Malaysia

2Pre-clinical Department, Faculty of Medicine and Defence Health, Kem Perdana Sungai Besi, 57000 Kuala Lumpur, Malaysia

3Center for Toxicology and Health Risk Studies (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

4Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia,
Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia

 

Diserahkan: 6 Disember 2022/Diterima: 7 Julai 2023

 

Abstract

The emergence of nanotechnology has become more popular, and the progress had sparked much development in nanoparticle synthesis, including selenium. Studies associated with the therapeutic abilities and physicochemical properties of selenium nanoparticles (SeNPs) are rapidly growing and gaining interest from many researchers. This review discusses on the fundamental components of selenium, different approaches in synthesizing selenium nanoparticles, its remedial properties and potential in biomedical application. Herein, primary focus will be given to the action of selenium nanoparticles mechanism in improving diabetes mellitus symptoms and complications in animal studies. It is known that selenium is an important micronutrient found in humans, plants and animals that can be incorporated as selenoprotein in the human body. Analysis and comparison on the findings enlighten that SeNPs demonstrated ameliorative effect on diabetes complications due to their antidiabetic, antioxidant, anti-inflammatory and lipid-lowering characteristics.

 

Keywords: Antidiabetics; diabetes mellitus; green synthesis; nanoparticle; selenium

 

Abstrak

Kemunculan nanoteknologi telah menjadi popular dan kemajuannya telah mencetus pelbagai perkembangan dalam sintesis nanozarah, termasuklah selenium. Kajian berkaitan dengan kebolehan terapeutik dan sifat fizikokimia selenium nanozarah (SeNPs) telah berkembang pesat dan mendapat tumpuan para penyelidik. Kajian ini membincangkan tentang komponen teras selenium, pendekatan berbeza dalam sintesis nanozarah selenium dan kebolehan pemulihan serta potensi dalam aplikasi bioperubatan. Di sini, penulisan menjurus kepada mekanisme selenium nanozarah dalam memperbaiki simptom dan komplikasi kencing manis dalam kajian yang bermodelkan haiwan. Umumnya, selenium merupakan mikronutrien penting yang terdapat pada manusia, tumbuhan dan haiwan yang digunakan sebagai selenoprotein dalam tubuh manusia. Analisis dan perbandingan pada beberapa penemuan menjelaskan bahawa SeNPs menunjukkan kesan penyembuhan ke atas komplikasi kencing manis kerana ciri antidiabetis, antioksidan, anti-radang dan penurunan lipid.

 

Kata kunci: Antidiabetis; kencing manis; nanozarah; selenium; sintesis hijau

 

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*Pengarang untuk surat-menyurat; email: siti.hajar@upnm.edu.my

 

 

 

 

 

 

 

 

 

 

 

   

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